Statistical Analysis of Alzheimer ’s disease Images

Document Type : Original Article

Authors

1 Dept. of Computer Science and Eng., Faculty of Elect., Eng., Menoufia University, EGYPT

2 Department of Electronic and Electrical Communications, Faculty of Electronic Engineering, Menoufia University, EGYPT

3 Faculty of computers and information, Menoufia University, EGYPT.

Abstract

; "> Alzheimer's disease is the most common type of dementia which
has no cure nor imaging test for it. Diagnosis of the Alzheimer’s
disease (AD) still a challenge and difficult. An early diagnosis for
Alzheimer’s disease is very important to delay the progression of it.
This paper extract and analyze various important statistical
features of MRI brain medical images to provide better analysis to
discriminate among the different types of tissue and diagnose of
AD. These statistical features had been used for detection of the
abnormalities among different demented and non-demented MRI
AD images. Also, it investigates and builds up an efficient
Computer Aided Diagnosis (CAD) system for AD to assist the
medical doctors to easily diagnose the disease. Statistical,
structural, and textural features had been calculated for different
images and classified using the SVM classifier. In addition, this
paper proposes an algorithm to improve the performance of the
CAD system. The performance of the CAD system based on
statistical analysis and the proposed algorithm had been measured
using different metric parameters. The obtained results indicate
that the accuracy improved from 49% without using the proposed
algorithm to 100% using the proposed algorithm.

t-stroke-width: 0px; "> [1] Alzheimer’s Association. 2015 Alzheimer’s disease Facts and Figures.
Alzheimer’s & Dementia 2015.
[2] A. Wimo and M. Prince, “World Alzheimer Report 2010: The global
economic impact of dementia,” 2010.
[3] P. Padilla, M. López, J. Górriz, J. Ramírez, D. Salas-González, I. Álvarez,
and The Alzheimer’s Disease Neuroimaging Initiative, “NMF-SVM Based
CAD Tool Applied to Functional Brain Images for the Diagnosis of
Alzheimer’s Disease”, IEEE TRANSACTIONS ON MEDICAL
IMAGING, VOL. 31, NO. 2, 2012, pp. 207-216.
; -webkit-text-size-adjust: auto; -web[4] F.J. Martinez-Murcia , J.M. Gorriz , J. Ramirez , C.G. Puntonet , D. SalasGonzalez or the Alzheimer’s Disease Neuroimaging Initiative, “Computer
Aided Diagnosis tool for Alzheimer’s Disease based on Mann–Whitney
Wilcoxon U-Test”, Expert Systems with Applications 39 (2012) 9676–
9685.
[5] R. Chaves, J. Ramirez a, J.M. Gorriz, C.G. Puntonet , Alzheimer’s Disease
Neuroimaging Initiative, “Association rule-based feature selection method
for Alzheimer’s disease diagnosis”, Expert Systems with Applications ,
2012.
[6] M. Sharma, R. Dubey2, Sujata, and S. Gupta, “Feature Extraction of
Mammograms”, International Journal of Advanced Computer Research,
Vol. 2, No. 3, Issue 5, 2012, pp. 201 209.
[7] P. Telagarapu, and S. Poonguzhali, “Analysis of Contourlet Texture
Feature Extraction to Classify the Benign and Malignant Tumors from
Breast Ultrasound Images”, International Journal of Engineering and
Technology, Vol 6 No 1, 2014, pp. 239 305.
[8] S. Karthikeyan, and N. Rengarajan, “Analysis of Gray Levels for Retinal
Image Classification”, Australian Journal of Basic and Applied Sciences,
Vol. 7, No.13, 2013, pp. 58-65.
[9] N. Zulpe1 and V. Pawar, “GLCM Textural Features for Brain Tumor
Classification”, IJCSI International Journal of Computer Science Issues,
Vol. 9, Issue 3, No 3, 2012, pp. 354 359.
[10] [10] A. Simpson, R. Do, E. Parada, M. Miga, and W. Jarnagin, “Texture
Feature Analysis for Prediction of Postoperative Liver Failure Prior to
Surgery”, SPIE Medical Imaging conference, 2014.
[11] S. Manikandan, V. Rajamani, and N. Murugan, “Analysis of Ultra Sound
Kidney Image Features for Image Retrieval by Gray Level Co-Occurrence
Matrices”, Lecture Notes on Software Engineering, Vol. 1, No. 1, 2013,
pp. 94 97.
[12] OASIS Database: http://www.oasis-brains.org/
[13] D. Marcus, T. Wang, J. Parker, J. Csernansky, J. Morris and R. Buckner,
“Open access series of imaging studies (OASIS): cross-sectional MRI data
in young, middle aged, nondemented, and demented older adults,” Journal
of Cognitive Neuroscience, vol. 19, no. 9, pp. 14981507, 2007.
[14] J. Toriwaki, H. Yoshida, “Fundamentals of Three-Dimensional Digital
Image Processing”, Springer-Verlag London Limited, 2009.
[15] HeterogeneityCAD module with 3D slicer:
http://wiki.slicer.org/slicerWiki/index.php/Documentation/Nightly/Module
s/HeterogeneityCAD
[16] Hugo J. Aerts, Emmanuel R. Velazquez, and Ralph T. Leijenaar,
“Decoding tumor phenotype by noninvasive imaging using a quantitative
radiomics approach”, Nature Communications, Nature Communications 5:
Article number: 4006; 2014.