A Multi Compartmental model for Targeted Drug Delivery Based on Internet of Biological NanoThings

Authors

1 Department of pure mathematics and Computer Science, Faculty of Science, Menoufia University Egypt and Department of Computer Science, Modern Academy at Maadi, Egypt

2 Department of Electronics and Electrical Communications Engineering, Faculty of Electronic Engineering, Menoufia University, Menouf 32952, Egypt.

3 Department of Mathematics and Computer Science, Faculty of Science Menoufia University, Shebin El-Koom , Egypt.

4 Machine Intelligence Department, Faculty of Artificial Intelligence, Menoufia University, Shebin El-Koom, Egypt.

Abstract

The authors propose a multi-compartmental model based on molecular communication (MC) technology for drug delivery to the malignant cell without affecting healthy cells in the patient's body. The medical personnel can transfer/control the required drug to the targeted cell with the help of a group of bio-nanomachines connected to the Internet of biological Nano Things (IoBNT) and a bio-cyber interface in both the forward and reverse directions. The proposed model consists of a set of multi-differential equations that are used to identify molecular communication among bio-nanomachines and quantify drug concentration to the targeted cell. Unlike conventional compartmental models, the proposed model can deliver the desired drug to the targeted cell by accounting for extracellular and intracellular tumor compartments, resulting in fewer therapeutic doses with improved efficacy. Simulations were also carried out to evaluate the performance of proposed multi-compartmental model with changing the physical parameters.

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